Publications

Publications

Virology: Antiviral Methods and Protocols.

                   Books in Print:

  • 1. Derek Kinchington and Raymond Schinazi, 2000. Editors. Antiviral Methods and Protocols. Methods in Molecular Medicine series published by Human Press, 2000.

                   Chapters in print:

  • 2. Donna Devine, Naomi Mathews and Derek Kinchington, 2000. Testing compounds for antiviral activity in cell cultures infected with HIV. In ‘Antiviral Methods and Protocols’. Edited by Derek Kinchington and Raymond Schinazi.
  • 3. Derek Kinchington and Sally Redshaw. Inhibitors of HIV proteinase, 1995. In Antiviral Chemotherapy edited by D.J Jeffries and E de Clercq. Wiley.
  • 4. Derek Kinchington, Hillar Kangro and Donald J. Jeffries, 1995. Design and testing of Antiviral Compounds. In Medical Virology: A practical Approach, edited by U. Desselberger. Oxford University Press.
  • 5. Derek Kinchington and Eleanor Berrie, 1987. Separation and maintenance of primary T- and B-lymphocytes. In ‘Basic Cell Culture and Protocols’. Edited by Jeffrey W. Pollard and John M. Walker. Humana Press. Second Edition: Derek Kinchington and Tony Ng, 1997.  

Virology: Refereed Journals

                   Smallpox virus:

  • 6. A. Hamilton, D.Kinchington, P.J. Greenaway, K.R. Dumbell, 1985. Recombinant bacterial plasmids containing inserts of variola DNA. Lancet   2: 1536-1537
  • 7. D. Kinchington, A.A. Dollery, P.J. Greenaway, K.R. Dumbell, 1984. The detection of subtle differences between different orthopoxviruses genomes by heteroduplex analysis. Virus Research 1: 351-363.

Human Immunodeficiency Virus

                   Proteinase inhibitors

  • 8. N.P.Camp, D.A. Perrey, D. Kinchington, P.C.D. Hawkins, and D. Gani, 1995. Synthesis of peptide analogues containing phosphonamidate methyl ester functionality: HIV-1 proteinase inhibitors possessing unique cell uptake properties. Bioorganic & Medicinal Chemistry: 3 (3), 297-312.
  • 9. S. Galpin,   N.A. Roberts, T. O’ Connor, D.J. Jeffries, D. Kinchington, 1993.   Antiviral properties of the HIV proteinase inhibitor RO 31-8959. Antiviral Chemistry and Chemotherapy 5: 43-45
  • 10. N.A. Roberts, J.A. Martin, D. Kinchington, A.V. Broadhurst, J. C. Craig,   I.B. Duncan, S.A. Galpin, B.K. Handa, J. Kay, A. Krohn, R.W. Lambert, J.H. Merrett, J.S. Mills, K.E.B. Parks, S. Redshaw, A.J. Ritchie, D. L. Taylor, G.J. Thomas and P. Machin, 1990. Rational design of Peptide-based HIV proteinase Inhibitors. Science 248: 358-361. 
  • 11. D. Kinchington, S.A. Galpin, T. J. O’Connor, D. J. Jeffries, J. D. Williamson, 1989. Comparison of antigen capture assays against HIV-1 in evaluating antiviral compounds. AIDS 3: 101-104.

                   Nucleoside analogues

  • 12. Wong-Kai-In, K.E.B. Parkes, D. Kinchington, S. Galpin, A.L. Hope, N.A. Roberts, J.A. Martin, J.H. Merrett, P. Machin & G. Thomas, 1991. Biological and biochemical studies on R0 31-6840 (2’ßFddC), a dideoxynucleoside analogue active against human immunodeficiency virus type 1(HIV-1). Nucleosides and nucleotides 10(1-3): 401-404.
  • 13. J.A. Martin, D.J. Bushnell, I.B. Duncan, S.G. Dunstan, M.G.Hall, P. Machin, J.H. Merrett, K.E.B. Parks, N.A. Roberts, G.J. Thomas, S.A. Galpin and D. Kinchington, 1990. Synthesis and antiviral activity of mono and di-fluoro analogues of pyrimidine deoxyribonucleosides against the human immunodeficiency virus. Journal of Medicinal Chemistry 33: 2137- 2145.

                   Nucleotide analogues

  • 14. C. McGuigan, S. Turner,   S.R. Nicholls, T.J. O’ Connor and D. Kinchington, 1994. Haloalkyl phosphate derivatives of AZT as inhibitors of HIV: Studies on the phosphate region. Antiviral Chemistry and Chemotherapy: 5(3), 162-168.
  • 15. D.L Cooper, K. A. Mort, N. L. Allan, D. Kinchington and C. McGuigan, 1993. Molecular similarity of anti-HIV phospholipids. Journal of the American Chemical Society 115:12615-12616.
  • 16. C. McGuigan, D. Kinchington, M Fang Wang, S.R. Nicholls, C. Nickson S. Galpin, D.J. Jeffries and T.J. O’Connor, 1993.   Nucleotide analogues previously found to be inactive against HIV may be activated by simple chemical means. FEBS Letters 322:249-252.
  • 17. C. McGuigan, D. Kinchington, S.R. Nicholls, C. Nickson and T.J. O’ Connor, 1993.   Kinase bypass: A new strategy for anti-HIV drug design. Bioorganic and Medicinal Chemistry Letters 13: 1207-1210.
  • 18. C. McGuigan, R.N. Pathirana, S.S.M. Choi, T. J. O’Connor and D. Kinchington, 1992. Phosphoramidate derivatives of AZT as inhibitors of HIV: studies on the carboxyl terminus. Antiviral Chemistry and Chemotherapy 4: 97-101.
  • 19. C. McGuigan, C. Nickson, T.J. O’Connor, D. Kinchington, 1992. Synthesis and anti-HIV activity of some novel lactyl and glycoyl phosphate derivatives. Antiviral Research 17: 197-212.
  • 20. D. Kinchington, J. Harvey, T. O’Connor, B.C.N.M. Jones, K.G. Devine, D. Taylor-Robinson, D.J. Jeffries and C. McGuigan, 1991. Comparison of activities of zidovudine phosphoramidate and phosphorodiamidate derivatives against HIV and ULV in vitro. Antiviral Chemistry and Chemotherapy 2: 107-112.
  • 21. C. McGuigan, T. O’ Connor, B. Swords and D. Kinchington, 1991. Simple phospholipids have selective anti-HIV activity.   AIDS 5: 1536-1537. 
  • 22. C. McGuigan, B.C.N.M. Jones, K.G. Devine, S. R. Nicholls, T. J. O’Connor and D. Kinchington, 1991. Attempts to introduce chemotherapeutic nucleotides into cells: studies on the anti-HIV agent FDT. Bioorganic and Medicinal Chemistry Letters 12: 729-732.
  • 23. C. McGuigan, K.G. Devine, T.J. O’Connor, D. Kinchington, 1991. Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3′-Azido-3′-deoxythymidine (AZT). Potent activity of the trichloroethyl methoxyalaninyl compound. Antiviral Research 15: 255-263.
  • 24. McGuigan, T.J. O’ Connor, S.R. Nichols, C. Nickson, D. Kinchington, 1991. Synthesis and anti-HIV activity of some novel substituted dialkyl phosphate derivatives of AZT and ddCyd. Antiviral Chemistry and Chemotherapy   1: 355-360. 
  • 25. B.C.N.M. Jones, C. McGuigan, T.J. O’Connor, D.J. Jeffries, D. Kinchington, 1991. Synthesis and anti-HIV activity of some novel phosphorodiamidate derivatives of 3′-Azido-3′-deoxythymidine (AZT). Antiviral Chemistry and Chemotherapy 2: 35-39.
  • 26. D. Curley, C. McGuigan, K.G. Devine, T.J. O’ Connor, D. Kinchington, 1990. Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity. Antiviral Research 14: 345-365.
  • 27. B. Betbeder, D.W. Hutchinson, T.O.L. Richards, N. Mahmood, D. Kinchington, 1990. The enzymatic synthesis and anti HIV-1 activity of 9-B-D-2′, 3′-dideoxynucleosides of N (6)-substituted purines. Antiviral Chemistry and Chemotherapy 4: 249-255.
  • 28. C. McGuigan, K.G. Devine, T.J. O’Connor, S.A. Galpin, D.J. Jeffries, D. Kinchington, 1990. Synthesis and evaluation of some novel phosphoramidate derivatives of 3′-modified nucleosides as anti-HIV compounds. Antiviral Chemistry and Chemotherapy 1: 107-113. 
  • 29. C. McGuigan, S.R. Nicholls, T.J. O’Connor, D. Kinchington, 1990. Synthesis of some novel dialkyl phosphate derivatives of 3′-modified nucleotides as potential anti-AIDS drugs. Antiviral Chemistry and Chemotherapy 1: 25- 33.
  • 30. K.V. Devine, C. McGuigan, T. O’Connor, S.R. Nicholls, D. Kinchington, 1990. Novel phosphate derivatives of AZT as anti-HIV compounds. AIDS 4: 371-372. 

                   Virucidal agents

  • 31. T.J. O’Connor, D. Kinchington, H.O. Kangro and D.J. Jeffries, 1995. The activity of candidate virucidal agents and genital secretions against HIV-1 in vitro. International Journal of STD and AIDS: 267-272.

Collaborative Study

  • 32. H.C. Holmes, N. Mahmoud, A. Karpas, J. Petric, D. Kinchington, T.O’ Connor, D.J. Jeffries, E. De Clercq, R. Pauwels, J. Desmyter and A. Hay, 1991. Screening of compounds for activity against HIV: a collaborative study. Antiviral Chemistry and Chemotherapy 2: 287-293.

Antisense oligodeoxynucleotides

  • 33. D. Kinchington, S. Galpin, J. Jaroszewski, K. Ghosh, C. SubaSinghe and J. Cowen, 1991. Gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1. Antiviral Research 17: 53-62.

Membranes as a target for chemotherapy

  • 34. D.R. Harper, R Gilbert, TJ O’Connor, D. Kinchington, DJ Jeffries, N. Mahood, RAJ McIlhinney and C. Blunt, 1996. Antiviral activity of 2-hydroxy fatty acids. Antiviral Chemistry and Chemotherapy: 7(3), 138-141.
  • 35. D. Kinchington, S.   Randall, M. Winther and   D.   Horrobin, 1993. Lithium gamma-linolenate -induced cytotoxicity against cells chronically infected with HIV-1. FEBS Letters 330:219-221 
  • 36. D. Kinchington, B. Barker, S. Galpin and K. Apostolov, 1992. Temperature enhancement of syncytia formation by HIV and Sendai virus. J. Medical Virology 36: 44-48 
  • 37. K. Apostolov, W. R. Barker, S. Galpin, N. A. Habib, C. B. Wood and D. Kinchington, 1989. Syncytia formation in HIV-1 infected cells is associated with an increase in cellular oleic acid. FEBS Letters 2: 241-244 

Immunomodulators

  • 38. D. Kinchington, T. Ng, N. Mathews, M. Tisdale, D. Devine and W. O. Ayuko, 1997. T-cell costimulation by a derivative of benzoic acid. Antiviral Chemistry and Chemotherapy: 8(2), 121-130. 

Virological review

  • 39. D. Kinchington, 1999.   Review: Recent Advances in Antiviral Therapy: Journal of Clinical Pathology. Vol. 52, No2, pp 89-94.

Cancer related studies.

  • 40. J. Haley, D. Kinchington, N. Whittle, M.D. Waterfield, A. Ullrich, 1987. The epidermal growth factor gene. In: Growth and Maturation Factors 4: 43-107.   Ed. G. Guroff, published by J. Wiley and Sons, New York.

                   EGF Receptor:

  • 41. J. Haley, N. Whittle, P. Bennett, D. Kinchington, A. Ullrich, M. Waterfield, 1987. The human EGR receptor gene: Structure of the 110 kb Locus and identification of sequences regulating its transcription. Oncogene Research 1: 375 – 396.

Epstein-Barr Virus:

  • 42. D. Kinchington, B.E. Griffin, 1987. Size heterogeneity of EBV and mitochondrial DNAs in Burkitt’s lymphoma lines. Nucleic Acid Research 15: 10345-10354.

Anticancer agents

  • 43. E. Lattmann, D.Kinchington, S.Dunn, H.Singh, W.O. Ayuko, M.J. Tisdale, 2004. Cytotoxicity of 3, 4-dihalogenated 2(5H)-furanones. Journal of Pharmacy and Pharmacology.  2004, 55, 1163-1170.
  • 44. E. Lattmann, W.O. Ayuko, D. Kinchington, C. A. Langley, L. Karimi, H.Singh and M. J. Tisdale, 2003. Synthesis and Evaluation of 5-Arylated 2(5H)-Furanones and 2-Arylated Pyridazin-3(2H)-ones as Anticancer Agents. Journal of Pharmacy and Pharmacology. 55, 1259-1265.
  • 45. E.Lattmann, D. Kinchington, H.Singh, I Merino, A. Begum, W.Ayuko and M.J. Tisdale, 2001. Synthesis of simple and bis-cyclic 3, 4-dihalogenated 2(5H)-furanones and their evaluation as novel cytotoxic agents. Pharmaceutical and Pharmcological Letters. 11, 5-8.

Calcification: PhD Studies

46. D.Kinchington,1980. Calcification processes in cool temperate corals. A thesis presented for the Degree of Doctor of Philosophy in the University of London, King’s College.

47. D. Kinchington, 1978. Localisation of intracellular calcium within the epidermis of a cool temperate coral. In: Developmental and Cellular Biology of Coelenterates. Eds. P.Tardent and R.Tardent. Proceedings of the 4th International Coelenterate Conference, Interlaken, Switzerland. Published by Elsevier North-Holland.

48. P.R.G. Tranter, D.N.Nicholson and D. Kinchington, 1982. A description of spawning  and   post-gastrula development of the cool temperate coral, Carophyllia Smithi. Journal of the Marine Biological Association, U.K. 62,845-854.

D. Kinchington, 1981. Organic-matrix synthesis by scleratinian coral larval and post- larval stages during skeletogenesis. In: Proceedings of the Fourth International Coral Reef Symposium, Manila, Volume 2. Published by Marine Sciences Centre, University of Philippines.